The role of TP53 network in the pathogenesis of chronic lymphocytic leukemia.
نویسندگان
چکیده
TP53 is one of the most important prognostic factors in chronic lymphocytic leukemia (CLL). Modulation of microRNAs by TP53 in CLL pathogenesis has been a hotspot. Besides, it has an intimate association with other cytogenetics and plays an important part in drug resistance of CLL. All above indicate an embedded TP53-centered network in CLL pathogenesis and prognosis. In this review, we focus on the TP53-centered network and its roles in the pathogenesis of CLL.
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ورودعنوان ژورنال:
- International journal of clinical and experimental pathology
دوره 6 7 شماره
صفحات -
تاریخ انتشار 2013